Genetic Testing for Hereditary Cancer

What is Hereditary Cancer?

There are more than 100 different types of cancer, majority of them occurring at older ages, in people with little or no family history of the disease and no genetic risk. These are named “Sporadic” cancers, which happen by chance.

“Hereditary’’ cancer on the other hand occurs in people who carry these mutations with them since birth. These people have inherited gene faults which puts them at higher risk for cancer than most others.

What is your risk for cancer?

A person with no family history of cancer is most likely at average risk, but for a person with a family history of cancer, genetic testing may help to determine the risk of developing cancer. If a person has had cancer, genetic testing may help to determine if there will be an increased risk for additional cancers.

Is hereditary cancer testing appropriate for you?

It may be appropriate if you have a personal or family history of any of the following:

  • More than one cancer in the same person
  • Multiple close family members (younger than 50 years old and of the same side) diagnosed with cancer
  • 3 or more close family members (of the same side) with different cancer types
  • Rare cancers at any age

How does genetic testing for hereditary cancer work?

The genetic test is done using a blood sample. Your sample, kept in a special kit will be sent to the genetic testing lab where genes are analysed for mutations, particularly those that may cause an increased risk of cancer.

Genetic Test Results

There are basically 3 possible results, namely:

  • Positive
    Mutation was found, hence increasing the risk of cancer to the specific gene that has mutation. This indicates that the person is a carrier of cancer, identify an increased risk of cancer in the future, or suggest a need for further testing.
  • Negative
    No changes or mutations found, hence the person is not afected, is not a carrier, or does not have an increased risk of developing cancer.
  • Inconclusive
    A genetic change was found, however unclear if it is caused by an increased risk for cancer or not. It cannot confirm or rule out and cannot indicate whether the person has an increased risk of developing cancer.

Recommendations

With the test results obtained, usually after 8 to 10 weeks, our doctor will discuss the prevention options and recommendations accordingly, whichever screening and treatment is more likely to be ideal.

Benefits of Hereditary Cancer Testing

By doing the test, it gives you a chance to better understand your risk for diagnosing with cancer. If a positive result is obtained, early treatment and decisions can be planned.

Genetic Testing for Inherited Cardiac Conditions

What is Inherited Cardiac Conditions?

Genetic can influence the risk for heart disease in many ways. Inherited cardiac conditions can affect people of any age and can be life threatening. As genes control every aspect of the cardiovascular system, one single variation (mutation) in one single gene can affect the likelihood of developing heart disease.

It is possible to have a faulty gene leading to a cardiac condition without developing any signs or symptoms. The common inherited cardiac conditions, to name a few may include:

• Long QT Syndrome
• Comprehensive Cardiomyopathy panel
• Dilated Cardiomyopathy panel
• Comprehensive Arrhythmia panel

What is your risk for Inherited Cardiac Conditions?

A person with no family history of cardiac condition is most likely at average risk, but for a person with a family history of such, genetic testing may help to determine the risk of developing any cardiac condition. If a person has had any cardiac conditions, genetic testing may help to determine if there will be an increased risk for additional ones.

Is hereditary testing for cardiac conditions appropriate for you?

It may be appropriate if you have a personal or family history of any of the following:

  • More than one cardiac conditions in the same person
  • Multiple close family members (younger than 50 years old and on the same side) diagnosed with cardiac conditions
  • 3 or more close family members (of the same side) with different cardiac conditions
  • Rare cardiac conditions at any age

How does genetic testing for hereditary Cardiac conditions work?

The genetic test is done using a blood sample. Your sample, kept in a special kit will be sent to the genetic testing lab where genes are analysed for mutations, particularly those that may cause an increased risk of some cardiac conditions.

Genetic Test Results

There are basically 3 possible results, namely:

  • Positive
    The mutation was found, hence increasing the risk of cardiac condition to the specific gene that has mutated. This indicates that the person is a carrier of that particular cardiac condition, identify an increased risk of some cardiac conditions in the future, or suggest a need for further testing.
  • Negative
    No changes or mutations found, hence the person is not affected, is not a carrier, or does not have an increased risk of developing any cardiac condition.
  • Inconclusive
    A genetic change was found, however unclear if it is caused by an increased risk for cardiac conditions or not. It cannot confirm or rule out and cannot indicate whether the person has an increased risk of developing any cardiac condition.

Recommendations

With the test results obtained, usually after 8 to 10 weeks, our doctor will discuss the prevention options and recommendations accordingly, whichever screening and treatment is more likely to be ideal.

Benefits of Hereditary Cardiac Condition Testing

By doing the test, it gives you a chance to better understand your risk for diagnosing with any cardiac diseases. If a positive result is obtained, early treatment and decisions can be planned.